Time to Upgrade your Brain
Are you working to reduce fatigue, anxiety, and brain fog? Do you want your thoughts to be smoother and more productive? Do you want to supercharge your brain for better learning and faster thinking without the side effects of stimulants?
Who doesn’t? That’s a big part of learning to be in the Bulletproof state of high performance. It’s something I strive for every day, always seeking new ways to be–and do–more.
That’s why, after years of testing, I’m excited to introduce a new substance that has risen above the rest as a safe, effective way to Bulletproof your brain: oxaloacetate, also known as OAA.
Shown to protect neurons in the brain from environmental toxins, OAA can also improve day-to-day brain function and may even help reduce age related conditions. There is also compelling animal evidence it can improve short term memory. A further side effect from animal studies is an increase the quantity and quality of life. A nice side effect, rating HIGH on my scale from 1 to Amazing.
Oxaloacetate is an anti-aging formula every Bulletproof person should consider for quality –and length – of life. Here’s why.
- It’s a nutritional supplement, not a drug. I’m not opposed to drugs when there is no natural replacement, but I’m comfortable because oxaloacetate is in many foods in small amounts, and it’s a critical metabolic compound in your body. I take it and my family uses it.
- Our oxaloacetate is from an extremely high quality source where impurities are ruthlessly flushed out and removed. You won’t get a ton of low quality fillers and stabilizers like you would from other supplements. And being thermally stabilized, you don’t have to store it at -40 degrees C.
- Upgraded Aging Formula vegi-caps are 100% soy-free, gluten-free, sugar-free, and contain no colorants, no flow agents, and no preservatives.
- Our oxaloacetate is in a form that is easily assimilated by your body, so it actually does its job and doesn’t just give you expensive urine. It’s water soluble, and PKA studies show it in the bloodstream 30 minutes after ingestion.
- This stuff has actual research behind it – a lot of research – that’s been verified by “being my own guinea pig”– the gold standard of the Bulletproof Executive.
- Our main recommendation for oxaloacetate is to upgrade your brain. Clear out that brain fog, stop repetitive/circular thoughts that slow you down and crystallize your real cognitive potential. And as if that weren’t enough there’s good evidence it does much more…read on below….
How oxaloacetate gives you the advantages of caloric restriction (without restricting calories)
Oxaloacetate is a calorie restriction mimetic. It takes advantage of the benefits of calorie restriction while saving you from the negatives.
In animals, calorie restriction can extend lifespan by up to 50%. 1, 2, 3, 4, 5, 6
There is little question calorie restriction extends life in animals, but it can cause problems for humans like low body temperature, muscle loss, cognitive dysfunction, and decreased quality of life. This dilemma has led researchers to look for substances that mimic the effects of calorie restriction, while avoiding the side effects.7, 8, 9, 10
Oxaloacetate is the most promising substance I’ve yet found. It extends lifespan in worms through similar mechanisms as calorie restriction.11
Rodent studies have shown similar effects.12 As you’ll see, this effect has a plethora of health benefits, many of which we are just beginning to understand. It programs genes for a longer life, it shields neurons from harmful amounts of glutamate, it protects mitochondria from DNA damage due to environmental toxins, and it may even help with age-related conditions.
How oxaloacetate programs your genes for maximum longevity
Animal models show that oxaloacetate tells genes to keep you alive longer than would normally be possible. Activating the AMPK-FOXO pathways through calorie restriction extends lifespan in worms.13 In vitro, oxaloacetate can increase NAD+ levels by 50%, which activates the AMPK-FOXO pathways.14 Oxaloacetate tells your genes to make you live longer.
|$49 for 1 bottle (30 capsules)|
Why your brain is in danger (and how oxaloacetate can help)
Oxaloacetate maintains healthy neurons in your brain and nervous system by insuring that there is no toxic build-up of glutamate in your head.
Glutamate is the most common neurotransmitter in your body.15 Monosodium glutamate (MSG) also raises glutamate levels in the human body. It is needed for learning and memory, but under the wrong conditions, it can kill neurons.16
In excess, glutamate excites your brain cells to death, which can lead to serious problems including cognitive decline.17 In particular, glutamate kills the cells that make myelin, the coating around your nerves that is needed for the creation of white matter.18
When everything is working right, glutamate levels in the brain are kept in a fine balance, with just enough being produced to support brain function without causing harm. However, chronic stress impairs glutamate metabolism so that excess glutamate accumulates in the brain.19
Over time, excess glutamate can cause mental impairment, sleep problems, and even more stress, all of which impairs glutamate recycling. This becomes a vicious cycle where stress leads to glutamate toxicity, and glutamate toxicity leads to more stress. Oxaloacetate can stop this cycle from continuing and allow continued normal functioning.
How oxaloacetate protects you from brain damage
- Oxaloacetate steps in and keeps glutamate from wreaking havoc on your brain. Injected oxaloacetate reduced brain glutamate levels in rats by 40%.20
- Not only does it reduce glutamate levels, it converts the harmful excess glutamate into fuel for neurons.21
- Injecting rats with oxaloacetate also reduced glutamate levels and protected neurons after traumatic head injury. 22, 23, 24, 25
- This results in improved brain function over the long term.26
- When oxaloacetate metabolism is blocked in animals that suffer a stroke, brain damage is far more severe.27
- Oxaloacetate has been shown to be more powerful than the other leading glutamate scavengers in animals.28
While the above research was done in animals, and we absolutely don’t recommend oxaloacetate for traumatic head injury or stroke, I think you can agree that this supplement is moving things in the right direction.29, 30
Oxaloacetate is water soluble, so it reaches almost every part of your body – including the inside of your brain.31
Oxaloacetate show a lot of promise for maintaining proper neurological support. For our purposes, I use it to clear out brain fog that can occur from stress accumulated glutamate buildup. I find my thoughts are “smoother” and it lowers my anxiety level so that I can make better decisions.
In short, oxaloacetate keeps your brain on the right course, and provides neurological system support. It allows you think better. However, oxaloacetate supports more than just brain cells.
How oxaloacetate supports your mitochondria
Damage to mitochondrial DNA is a major contributor to aging and other serious conditions. Loss of brain function is often preceded by a decline in mitochondrial function.
In vitro studies have shown that oxaloacetate protects against mitochondrial DNA damage from environmental toxins.32 Oxaloacetate also supports your DNA by increasing NAD+ levels in your cells, which shields DNA from free radical damage.33 In rats, oxaloacetate can reduce mitochondrial damage caused by excitotoxins.34
Oxaloacetate has also been shown to increase the protective effects of zinc on human eye cells in a test tube.35 By supporting your DNA and other tissues, oxaloacetate may reduce your risk of many age-related degenerative conditions.
As a side effect, it may also increase average and maximal lifespan.
What’s in Upgraded Aging Formula
There are 250mg of Upgraded Aging Formula in each capsule, and 30 capsules in 1 bottle. 100mg of each capsule is thermally stabilized oxaloacetate, and150mg is vitamin C.
Vitamin C is not just a filler–it’s a key ingredient. Vitamin C acts as an electron acceptor, stabilizing the oxaloacetate and preventing it from turning into pyruvate.
|$49 for 1 bottle (30 capsules)|
Click to read the complete list of references.
- Omodei D, et al. Calorie restriction and prevention of age-associated chronic disease. FEBS Letters. 2011 Jun 6;585(11):1537-42. http://www.ncbi.nlm.nih.gov/pubmed/21402069
- Kemnitz JW. Calorie restriction and aging in nonhuman primates. Institute of Laboratory Animal Research Journal. 2011 Feb 8;52(1):66-77. http://www.ncbi.nlm.nih.gov/pubmed/21411859
- Colman RJ. Nonhuman primate calorie restriction. Antioxidant & Redox Signaling. 2011 Jan 15;14(2):229-39. http://www.ncbi.nlm.nih.gov/pubmed/20698791
- Fontana L. Calorie restriction and cardiometabolic health. Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):3-9. http://www.ncbi.nlm.nih.gov/pubmed/18277179
- Weiss EP, et al. Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1205-19. http://www.ncbi.nlm.nih.gov/pubmed/21841020
- Speakman JR, et al. Caloric restriction. Mol Aspects Med. 2011 Jun;32(3):159-221. http://www.ncbi.nlm.nih.gov/pubmed/21840335
- Ingram DK. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006 Apr;5(2):97-108. http://www.ncbi.nlm.nih.gov/pubmed/16626389
- Ingram DK. Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci. 2004 Jun;1019:412-23. http://www.ncbi.nlm.nih.gov/pubmed/15247056
- Roth GS. Caloric restriction mimetics: the next phase. Ann N Y Acad Sci. 2005 Dec;1057:365-71. http://www.ncbi.nlm.nih.gov/pubmed/16399906
- Chiba T, et al. Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases. Curr Genomics. 2010 December; 11(8): 562–567. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078680/
11. Williams DS, et al. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009 Dec;8(6):765-8. http://www.ncbi.nlm.nih.gov/pubmed/19793063
- Cash A. Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction. Open Longevity Science, 2009, 3, 22-27. http://www.benthamscience.com/open/tolsj/articles/V003/SI0016TOLSJ/22TOLSJ.pdf
- Greer EL. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol. 2007 Oct 9;17(19):1646-56. http://www.ncbi.nlm.nih.gov/pubmed/17900900
- Haslam JM. The permeability of mitochondria to oxaloacetate and malate. Biochem J. 1968 May; 107(5): 659–667. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198718/
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr. 2000 Apr;130(4S Suppl):1007S-15S. http://www.ncbi.nlm.nih.gov/pubmed/10736372
- McEntee WJ. Glutamate: its role in learning, memory, and the aging brain. Psychopharmacology (Berl). 1993;111(4):391-401. http://www.ncbi.nlm.nih.gov/pubmed/7870979
- Djurici? B. [Glutamate in brain: transmitter and poison]. Glas Srp Akad Nauka Med. 2002;(47):55-76. http://www.ncbi.nlm.nih.gov/pubmed/16078441
- Matute C. Glutamate and ATP signalling in white matter pathology. J Anat. 2011 Jul;219(1):53-64. http://www.ncbi.nlm.nih.gov/pubmed/21250988
- Wikinski SI, et al. [Role of excitatory amino acids in neuropathology]. Medicina (B Aires). 1995;55(4):355-65. http://www.ncbi.nlm.nih.gov/pubmed/8728878
- Popoli M, et al. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nature Reviews Neuroscience 13, 22-37 (January 2012). http://www.nature.com/nrn/journal/v13/n1/pdf/nrn3138.pdf?WT.ec_id=NRN-201201
- Zlotnik A, et al. Brain neuroprotection by scavenging blood glutamate. Exp Neurol. 2007 Jan;203(1):213-20. http://www.ncbi.nlm.nih.gov/pubmed/17014847
- Rink C. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Antioxid Redox Signal. 2011 May 15;14(10):1777-85. http://www.ncbi.nlm.nih.gov/pubmed/21361730
- Nagy D, et al. Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex. Cell Mol Neurobiol. 2009 Sep;29(6-7):827-35. http://www.ncbi.nlm.nih.gov/pubmed/19259807
- Zlotnik A, et al. Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats. Anesthesiology. 2012 Jan;116(1):73-83. http://www.ncbi.nlm.nih.gov/pubmed/22129535
- Zlotnik A, et al. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J Neurosurg Anesthesiol. 2009 Jul;21(3):235-41. http://www.ncbi.nlm.nih.gov/pubmed/19543002
- Marosi M, et al. Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion. Eur J Pharmacol. 2009 Feb 14;604(1-3):51-7. http://www.ncbi.nlm.nih.gov/pubmed/19135048
- Campos F, et al. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. http://www.ncbi.nlm.nih.gov/pubmed/21266983
- Campos F, et al. Oxaloacetate: a novel neuroprotective for acute ischemic stroke. Int J Biochem Cell Biol. 2012 Feb;44(2):262-5. http://www.ncbi.nlm.nih.gov/pubmed/22085530
- Campos F, et al. Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels. Clin Sci (Lond). 2011 Jul;121(1):11-7. http://www.ncbi.nlm.nih.gov/pubmed/21265738
- Campos F, et al. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. http://www.ncbi.nlm.nih.gov/pubmed/21266984
- Yoshikawa K. Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med. 1968 Oct;96(2):127-41. http://www.ncbi.nlm.nih.gov/pubmed/4884771
- Johnson JD, et al. Stereochemistry and function of oxaloacetate keto-enol tautomerase. The Journal of Biological Chemistry. 1986 April; 261,4535-4541. http://www.jbc.org/content/261/10/4535.abstract
- McKiernan SH, et al. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2007 Jun;292(6):F1751-60. http://www.ncbi.nlm.nih.gov/pubmed/17344189
- Yudkoff M, et al. Brain amino acid metabolism and ketosis. J Neurosci Res. 2001 Oct 15;66(2):272-81. http://www.ncbi.nlm.nih.gov/pubmed/11592124
- Wood JP, et al. Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells. Neurochem Res. 2003 Oct;28(10):1525-33. http://www.ncbi.nlm.nih.gov/pubmed/14570397
- Farah IO. Differential modulation of intracellular energetics in A549 and MRC-5 cells. Biomed Sci Instrum. 2007;43:110-5. http://www.ncbi.nlm.nih.gov/pubmed/17487066