Bulletproof® Upgraded™ Aging Formula
Time to Upgrade your Brain
Are you working to reduce fatigue, anxiety, and brain fog? Do you want your thoughts to be smoother and more productive? Do you want to supercharge your brain for better learning and faster thinking without the side effects of stimulants?
Who doesn’t? That’s a big part of learning to be in the Bulletproof state of high performance. It’s something I strive for every day, always seeking new ways to be – and do – more.
That’s why, after years of testing, I’m excited to introduce a new substance that has risen above the rest as a safe, effective way to Bulletproof your brain: oxaloacetate, also known as OAA.
Shown to protect neurons in the brain from environmental toxins, OAA can also improve day-to-day brain function and may even help reduce age related conditions. There is also compelling animal evidence it can improve short term memory. A further side effect from animal studies is an increase the quantity and quality of life. A nice side effect, rating HIGH on my scale from 1 to Amazing.
Oxaloacetate is an anti-aging formula every Bulletproof person should consider for quality –and length – of life. Here’s why.
- It’s a nutritional supplement, not a drug. I’m not opposed to drugs when there is no natural replacement, but I’m comfortable because oxaloacetate is in many foods in small amounts, and it’s a critical metabolic compound in your body. I take it and my family uses it.
- Our oxaloacetate is from an extremely high quality source where impurities are ruthlessly flushed out and removed. We don’t use low quality fillers and stabilizers.
- Normally, oxoaloacetate degrades unless you store it at -40 degrees C, but we use a patented thermal stabilization process which prevents breakdown.
- Upgraded Aging Formula vegi-caps are 100% soy-free, gluten-free, sugar-free, and contain no colorants, no flow agents, and no preservatives.
- Our oxaloacetate is in a form that is easily assimilated by your body, so it actually does its job and doesn’t just give you expensive urine. It’s water soluble, and PKA studies show it in the bloodstream 30 minutes after ingestion.
- This stuff has actual research behind it – a lot of research – that’s also been verified by “being my own guinea pig”– the gold standard of the Bulletproof Executive.
- Our main recommendation for oxaloacetate is to upgrade your brain. Clear out that brain fog, stop repetitive/circular thoughts that slow you down and crystallize your real cognitive potential., And as if that weren’t enough there’s good evidence it does much more…read on below….
How oxaloacetate gives you the advantages of caloric restriction (without restricting calories)
Oxaloacetate is a calorie restriction mimetic. It takes advantage of the benefits of calorie restriction while saving you from the negatives.
In animals, calorie restriction can extend lifespan by up to 50%. (1)(2)(3)(4)(5)(6)
There is little question calorie restriction extends life in animals, but it can cause problems for humans like low body temperature, muscle loss, cognitive dysfunction, and decreased quality of life. This dilemma has led researchers to look for substances that mimic the effects of calorie restriction, while avoiding the side effects. (7)(8)(9)(10)
Oxaloacetate is the most promising substance I’ve yet found. It extends lifespan in worms through similar mechanisms as calorie restriction. (11)
Rodent studies have shown similar effects. (12)
As you’ll see, this effect has a plethora of health benefits, many of which we are just beginning to understand. It programs genes for a longer life, it shields neurons from harmful amounts of glutamate, it protects mitochondria from DNA damage due to environmental toxins, and it may even help with age-related conditions.
How oxaloacetate programs your genes for maximum longevity
Animal models show that oxaloacetate tells genes to keep you alive longer than would normally be possible. Activating the AMPK-FOXO pathways through calorie restriction extends lifespan in worms. (13)
In vitro, oxaloacetate can increase NAD+ levels by 50%, which activates the AMPK-FOXO pathways. (14)
Oxaloacetate tells your genes to make you live longer.
$49 for 1 bottle (30 capsules)
Why your brain is in danger (and how oxaloacetate can help)
Oxaloacetate maintains healthy neurons in your brain and nervous system by insuring that there is no toxic build-up of glutamate in your head.
Glutamate is the most common neurotransmitter in your body. (15) Monosodium glutamate (MSG) also raises glutamate levels in the human body.
It is needed for learning and memory, but under the wrong conditions, it can kill neurons. (16)
In excess, glutamate excites your brain cells to death, which can lead to serious problems including cognitive decline. (17)
In particular, glutamate kills the cells that make myelin, the coating around your nerves that is needed for the creation of white matter. (18)
When everything is working right, glutamate levels in the brain are kept in a fine balance, with just enough being produced to support brain function without causing harm. However, chronic stress impairs glutamate metabolism so that excess glutamate accumulates in the brain. (20)
Over time, excess glutamate can cause mental impairment, sleep problems, and even more stress, all of which impairs glutamate recycling. This becomes a vicious cycle where stress leads to glutamate toxicity, and glutamate toxicity leads to more stress. Oxaloacetate can stop this cycle from continuing and allow continued normal functioning.
How oxaloacetate protects you from brain damage
Oxaloacetate steps in and keeps glutamate from wreaking havoc on your brain.
Injected oxaloacetate reduces brain glutamate levels in rats by 40%. (21)
Not only does it reduce glutamate levels, it converts the harmful excess glutamate into fuel for neurons. (22)
Injecting rats with oxaloacetate reduces glutamate levels and protects neurons after traumatic head injury. (21)(23)(24)(25)
This results in improved brain function over the long term. (26)
When oxaloacetate metabolism is blocked in animals that suffer a stroke, brain damage is far more severe. (27)
Oxaloacetate has been shown to be more powerful than the other leading glutamate scavengers in animals. (28)
While the above research was done in animals, and we absolutely don’t recommend oxaloacetate for traumatic head injury or stroke, I think you can agree that this supplement is moving things in the right direction. It is also interesting to note that people who suffer a stroke and have high levels of oxaloacetate in their brains generally have a more complete recovery. (29) (30)
Oxaloacetate is water soluble, so it reaches almost every part of your body – including the inside of your brain. (31)
Thanks to its potent ability to lower glutamate levels, oxaloacetate is being considered for use as a therapeutic agent in cases of ischemic stroke. (28) Again, we don’t recommend this product for stroke, and we shall see if the FDA approves OAA for this function. In the mean time, however, I think you can agree that oxaloacetate show a lot of promise for maintaining proper neurological support. For our purposes, I use it to clear out brain fog that can occur from stress accumulated glutamate buildup. I find my thoughts are “smoother” and it lowers my anxiety level so that I can make better decisions.
In short, oxaloacetate keeps your brain on the right course, and provides neurological system support. It allows you think better. However, oxaloacetate supports more than just brain cells.
How oxaloacetate supports your mitochondria
Damage to mitochondrial DNA is a major contributor to aging and other serious conditions. Loss of brain function is often preceded by a decline in mitochondrial function.
In vitro studies have shown that oxaloacetate protects against mitochondrial DNA damage from environmental toxins. (32)
Oxaloacetate also supports your DNA by increasing NAD+ levels in your cells, which shields DNA from free radical damage. (33)
In rats, oxaloacetate can reduce mitochondrial damage caused by excitotoxins. (34)
Oxaloacetate has also been shown to increase the protective effects of zinc on human eye cells in a test tube. (35)
By supporting your DNA and other tissues, oxaloacetate may reduce your risk of many age-related degenerative conditions. As a side effect, it may also increase average and maximal lifespan, a great benefit.
What’s in Upgraded Aging Formula
Vitamin C is not just a filler–it’s a key ingredient. Vitamin C acts as an electron acceptor, stabilizing the oxaloacetate and preventing it from turning into pyruvate.
$49 for 1 bottle (30 capsules)
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22. Rink C. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Antioxid Redox Signal. 2011 May 15;14(10):1777-85. http://www.ncbi.nlm.nih.gov/pubmed/21361730
23. Nagy D, et al. Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex. Cell Mol Neurobiol. 2009 Sep;29(6-7):827-35. http://www.ncbi.nlm.nih.gov/pubmed/19259807
24. Zlotnik A, et al. Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats. Anesthesiology. 2012 Jan;116(1):73-83. http://www.ncbi.nlm.nih.gov/pubmed/22129535
25. Zlotnik A, et al. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J Neurosurg Anesthesiol. 2009 Jul;21(3):235-41. http://www.ncbi.nlm.nih.gov/pubmed/19543002
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33. McKiernan SH, et al. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2007 Jun;292(6):F1751-60. http://www.ncbi.nlm.nih.gov/pubmed/17344189
34. Yudkoff M, et al. Brain amino acid metabolism and ketosis. J Neurosci Res. 2001 Oct 15;66(2):272-81. http://www.ncbi.nlm.nih.gov/pubmed/11592124
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36. Farah IO. Differential modulation of intracellular energetics in A549 and MRC-5 cells. Biomed Sci Instrum. 2007;43:110-5. http://www.ncbi.nlm.nih.gov/pubmed/17487066