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#101 – Mark Sisson and His Primal Blueprint – Podcast

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Mark Sisson is a fat burning beast and one of the prime authorities in the Paleo-sphere today. On this episode of Bulletproof Radio, Mark talks about the concepts behind his top-performing book, The Primal Blueprint, and how they relate to a Bulletproof lifestyle. Have you ever looked at your body as its own life support system for ancient bacteria colonies? You’ll also hear about epigenetics, lectins, and how to get low-tech with a shit milkshake?  He’s articulate, full of upgraded knowledge, and has kick ass abs. Please enjoy!

Mark Sisson is the author of a #1 bestselling health book on, The Primal Blueprint, as well as The Primal Blueprint Cookbook and the top-rated health and fitness blog He is also the founder of Primal Nutrition, Inc., a company devoted to health education and designing state-of-the-art supplements that address the challenges of living in the modern world. In his own words: My life has been one built around health and fitness and I don’t plan for that to ever end. I’ve made it my personal goal to help 10 million people achieve their ultimate genetic potential.”

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What You’ll Hear

  •   0:00 – Cool Fact of the Day!
  •   0:40 – Welcome Mark Sisson
  •   1:35 – What is the Primal Blueprint
  •   4:25 – IBS, Arthritis, and Grains
  •   6:00 – Louise Hay
  •   6:25 – Paleo 3.0
  • 12:15 – What drives lifestyle choices?
  • 13:40 – Gene “Hack”man
  • 15:15 – Importance of epigenetics
  • 18:50 – Eugenics
  • 23:55 – Fecal Transplants
  • 24:50 – Helminthic Therapy
  • 27:55 – Lasers and ATP
  • 29:30 – Toxins and Lectins in Food
  • 36:50 – Resistant Starch and the Carbohydrate Curve
  • 40:45 – Gut Biome
  • 42:45 – Mold Toxins
  • 46:55 – Intermittent Fasting
  • 52:00 – Hormones, HGH, Testosterone
  • 53:30 – Top three recommendations for kicking more ass and being Bulletproof!


Mark’s Daily Apple

The Primal Blueprint


Louise Hay


Better Baby Book

Bulletproof Vibe

40 Years of Zen


Click here to view the transcript of Podcast #101 with Mark Sisson

Questions for the podcast?

Leave your questions and responses in the comments section below. If you want your question to be featured on the next Q&A episode, submit it in the Podcast Question form! You can also ask your questions and engage with other listeners through The Bulletproof ForumTwitter, and Facebook!


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  • Cheesus Christ

    OMG! Mark Sisson!

  • langdj

    You guys are competitors for the best nutrition content out there. It say a lot that you would have him on the show. At the end of the day you are both awesome and changing the world for a better place! I like to buy as much as I can from both of you guys, since you have made such a difference in my life

  • rockervortex

    was having one of the most productive days of the year, but had to drop everything and take an hour break to watch my two favorite people :) y’all ROCK!

  • Rachel Fleming

    What is the different discussion about intermittent fasting for women?

    • Susie Goldfish

      According to Dave we should IF but eat fat in the morning (Bulletproof Coffee w/MCT and butter). I believe that works for some women, but I gain weight and have digestive issues (constipation and bloating) if I just have Bulletproof Coffee in the morning. I have found that having Bulletproof Coffee and 2-3 poached eggs works quite well, however.

      My Bulletproof Coffee is actually 100% cacao or matcha with MCT and butter as I don’t drink coffee. That may where I go wrong.

      • Susie Goldfish

        I have been reading Paul Jaminet on Candida. He says that Candida can become adapted to ketones and stronger for it. I am battling quite strong gut dysbiosis/leaky gut with candida overgrowth, so on my version of Bulletproof coffee ended up feeding the candida every morning.

        I have added more carb and resistant starch to my breakfast. Hopefully I will get a handle on my gut issues soon.

    • Darcie Gurley
  • Skilluck

    Finally Mark Sisson on the podcast! This guy has given me so much over the years, his blog is really excellent.

  • Jordan

    Thanks to this episode I now know how to pronounce ‘autophagy’.. boy did I have it wrong before.

  • GTR

    Beging somewhat petic here: Do Dave’s problems with Resistant Starch mean that he is in some kind of local optimum? It clearly looks like the globally best diet available should include RS. And that junk food eaters have a clear path there, towards – they are so low, that the path to the global maximum leads always upwards, that is with constant improvements to their diet. Now how about Dave who is on one of the peaks, but not the RS-including highes ones? Perhaps the classic road there leads through temporary problems? Maybe there’s another soultion like helicpotering yourself from one peak to another? Who knows the answer?

    • Ron Paul End the Fed

      Dave definitely needs to get Nikoley / Tater Tot on the show!

  • SoulBioHack-LondonGirl

    Perhaps my two favourite life-hacking gurus. So exciting to see you two exchange information.

  • verdun707

    While expressing reservations about resistant starch, Dave refers more than once in the interview to raw potato “flour” instead of starch, a very different thing. Could it be that Dave’s experience results from using potato flour instead of starch? I do believe I heard Dave refer to potato flour as well in his recent interview with JJ VIrgin. Also – is it actually such a shock to discover iceberg-borne microbes among the species of gut bacteria in one who happens to live cheek by jowl with icebergs and glaciers?

    • Ron Paul End the Fed

      Good point.

      • Marcus

        I noticed this too – Raw Potato Flour (RPF) is NOT a source of resistant starch and if someone has issues with nightshades or blood glucose control, taking RPF will make it worse. Potato Starch (PS) is just that, (resistant) starch from potatoes, nothing else. Anyone experiencing BG spikes or hives and rashes after starting RS should go back and look closely at the label on their RS – if it is potato flour instead of potato starch, that might be the cause.

        Bobs Red Mill, a common source, sells both;

  • Cate

    Potato Starch made all my joints hurt and I didn’t realize what was going on for about two weeks, because I am dense and I kept blaming my new running shoes. Finally I heard/ read that bit about alkaloids and nightshades. Are white potatoes really high in lectins? Yikes, I am done with that stuff. I was only doing it out of curiosity but w/o the starch I don’t have any problems and eat PHD.

  • Jonathan Roseland

    “Mitochondrial biogenesis… If we want to talk about a hack the greatest thing you can do for your body is increase the number and efficiency of Mitochondria”

  • Mom

    Two great respectable guys in the field of health & nutrition. But i cant help but notice & compare the depth of knowledge between the two. Mark knows a lot but shallow general info. Dave can really get down to the scientific processes and terminologies. But I love these two boys evenly! :)

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  • oneshot2shots

    61??? are you fricking kidding me??